Antioxidant Strategy to Prevent Simulated Microgravity-Induced Effects on Bone Osteoblasts

Simulated microgravity-induced aortic remodeling.

We have previously shown that microgravity and simulated microgravity induce an increase in human and rat aortic stiffness. We attempted to elucidate the mechanism(s) responsible for this increase in stiffness. We hypothesize that an alteration in vessel wall collagen or elastin content or in extracellular matrix (ECM) cross-linking either individually or in a combination is responsible for the...

Microgravity and drug effects on bone.

Food restriction and simulated microgravity: effects on bone and serum leptin.

Leptin is responsible for linking energy metabolism to bone mass. Because astronauts are commonly in negative energy balance during spaceflight, this study was designed to assess individual and combined effects of food restriction and simulated microgravity on bone mass and serum leptin. Six-month-old male Sprague-Dawley rats were randomly assigned to four groups (n = 12 each): two hindlimb-unl...

Effects of Simulated Microgravity on Thermotolerance of Pea Seedlings

A coordinated plant response to simulated microgravity (clinorotation) and heat stress was analyzed. 5-d pea seedlings grown on a horizontal clinostat or in the stationary conditions were exposed to different heat treatments (mild, severe and severe after pretreatment). Temperature-dependent quantitative changes in the heat stress response were revealed in the clinorotated seedlings comparative...

The effects of simulated microgravity on cultured chicken embryonic chondrocytes.

Using the cultured chicken embryonic chondrocytes as a model, the effects of simulated microgravity on the microtubular system of the cellular skeleton, extracellular matrix, alkaline phosphatase activity, intracellular free calcium concentration and mitochondrial ATP synthase activity with its oligomycin inhibition rate were studied with a clinostat. The microtubular content was measured by a ...